Dry fabrication of poly(<i>dl</i>-lactide-co-glycolide) microspheres incorporating a medium molecular drug by a ball mill method
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چکیده
منابع مشابه
Encapsulation of Naja –Naja Oxiana Snake venom into Poly (lactide-co-glycolide) microspheres
One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...
متن کاملModulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres.
BACKGROUND Biodegradable poly(lactide- co -glycolide) (PLGA) microspheres are a promising carrier for vaccine delivery capable of maturing antigen-presenting cells to stimulate T-cell-mediated immune responses. However, the potential of microspheres to downregulate an allergic response in vivo is unknown. OBJECTIVE The aim of this study was to determine whether microspheres could potentiate D...
متن کاملStabilization of a model formalinized protein antigen encapsulated in poly(lactide-co-glycolide)-based microspheres.
A formaldehyde-mediated aggregation pathway (FMAP) has been shown to be primarily responsible for the solid-state aggregation of lyophilized formalinized protein antigens [e.g., tetanus toxoid (TT) and formalinized bovine serum albumin (f-BSA)] in the presence of moisture and physiological temperature. Coincorporation of the formaldehyde-interacting amino acid, histidine, strongly inhibits the ...
متن کاملMicroencapsulation of recombinant interferon a-2b into poly (D,L-lactide-co-glycolide) microspheres
Interferon-α2b (IFN-α2b) produced in Cuba by the Center for Genetic Engineering and Biotechnology was encapsulated into poly (D,L-lactide-co-glycolide) (PLGA) microspheres using the double emulsion-solvent evaporation method. Resulting microspheres showed smooth surfaces containing randomly distributed pores, a mean diameter of 28.1 ± 0.4 μm (using 14,000 rpm for the second emulsification step)...
متن کاملPoly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system.
Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of ad...
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ژورنال
عنوان ژورنال: Drug Discoveries & Therapeutics
سال: 2021
ISSN: 1881-7831,1881-784X
DOI: 10.5582/ddt.2021.01004